BDBM356237 US10604535, Example 7::US9815850, Compound 7::US9896458, No. 7

SMILES CN1c2ccccc2C2CC2[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O

InChI Key InChIKey=PMQJFOOLSKEIKZ-NGICGMGXSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 356237   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM356237(US10604535, Example 7 | US9815850, Compound 7 | US...)
Affinity DataIC50:  500nMAssay Description:Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM356237(US10604535, Example 7 | US9815850, Compound 7 | US...)
Affinity DataIC50: <1.00E+3nMAssay Description:Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM356237(US10604535, Example 7 | US9815850, Compound 7 | US...)
Affinity DataIC50:  500nMAssay Description:Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent