BDBM35847 (15S)-prostaglandin E2::(5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid::(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid::(E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid::CHEMBL548::DINOPROSTONE::PGE2::[3H]Dinoprostone::[3H]PGE2::[3H]Prostaglandin E2::prostaglandin E2
SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
InChI Key InChIKey=XEYBRNLFEZDVAW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 83 hits for monomerid = 35847
Affinity DataEC50: 0.0200nMAssay Description:Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 ...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 0.583nMAssay Description:Agonist activity at human EP4 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity against rat EP4 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseMore data for this Ligand-Target Pair
Affinity DataKi: 0.790nMAssay Description:Binding affinity at human prostaglandin EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.790nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.790nMAssay Description:Displacement of [3H]PGE4 from human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.940nMAssay Description:Binding affinity to EP3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataEC50: 2.10nMAssay Description:Agonist activity at EP2 receptor (unknown origin) by functional assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of rat EP4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at human EP4 receptor by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]prostaglandin E2 from recombinant human full length EP3 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Binding affinity to EP4 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 3.5nMAssay Description:Agonist activity at rat EP4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Agonist activity at human EP1 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Displacement of [3H]PGE2 from human EP2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Binding affinity at human prostaglandin EP2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]prostaglandin E2 from recombinant human full length EP4 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Binding affinity to EP3 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of rat EP2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 7.5nMAssay Description:Agonist activity at human EP4 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptorMore data for this Ligand-Target Pair
