BDBM361221 (R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]pyridin-6- yl)-3-(2H-tetrazol- 5-yl)benzene-1,2- disulfonamide::US10221163, Example 378::US10544130, Example 378

SMILES NC[C@@H](N)CNS(=O)(=O)c1ccc(-c2cnc3cc[nH]c3c2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=CXRCAVIUGHWDFE-QLWWJYNRSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361221   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361221((R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]p...)
Affinity DataIC50:  0.354nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361221((R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]p...)
Affinity DataIC50:  0.0510nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase()
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361221((R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]p...)
Affinity DataIC50:  0.0980nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361221((R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]p...)
Affinity DataIC50:  0.354nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361221((R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]p...)
Affinity DataIC50:  0.0510nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361221((R)-N1-(2,3- diaminopropyl)-4-(1H- pyrrolo[3,2-b]p...)
Affinity DataIC50:  0.0980nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent