BDBM361321 (R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fluoropyridin-3-yl)-3-(2H- tetrazol-5-yl)benzene-1,2- disulfonamide::US10221163, Example 478::US10544130, Example 478

SMILES NC[C@@H](O)CNS(=O)(=O)c1ccc(-c2cnc(N)c(F)c2)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361321   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361321((R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50:  0.677nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361321((R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50:  0.159nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase()
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361321((R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50:  0.0910nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361321((R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50:  0.677nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361321((R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50:  0.159nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361321((R)-N1-(3-amino-2- hydroxypropyl)-4-(6-amino-5- fl...)
Affinity DataIC50:  0.0910nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent