BDBM362565 (4S)-2-[(2S)-4-acetyl-2-methylpiperazin-1- yl]-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin- 2-yl-4,5-dihydroimidazo[1,5,4-de][1,4] benzoxazine::US10227359, Example 3::US10618910, Example 3::US9834565, Example 3

SMILES C[C@H]1CN(CCN1c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23)C(C)=O

InChI Key InChIKey=XGTBENVKMVXFJO-OYHNWAKOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 362565   

TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362565((4S)-2-[(2S)-4-acetyl-2-methylpiperazin-1- yl]-7-(...)
Affinity DataIC50:  62nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362565((4S)-2-[(2S)-4-acetyl-2-methylpiperazin-1- yl]-7-(...)
Affinity DataIC50:  63nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362565((4S)-2-[(2S)-4-acetyl-2-methylpiperazin-1- yl]-7-(...)
Affinity DataIC50: <25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362565((4S)-2-[(2S)-4-acetyl-2-methylpiperazin-1- yl]-7-(...)
Affinity DataIC50:  62.5nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362565((4S)-2-[(2S)-4-acetyl-2-methylpiperazin-1- yl]-7-(...)
Affinity DataIC50: <25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [342-460](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362565((4S)-2-[(2S)-4-acetyl-2-methylpiperazin-1- yl]-7-(...)
Affinity DataIC50: <25nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent