BDBM363475 9-(2-(4-(1H-tetrazol-1- yl)phenyl)-2-hydroxyethyl)-4-(4- methyl-5-oxo-2,5-dihydrofuran- 3-yl)-1-oxa-4,9- diazaspiro[5.5]undecan-5-one (single enantiomer, absolute stereochemistry not established)::US9850245, Example 9A

SMILES CC1=C(COC1=O)N1CCOC2(CCN(CC(O)c3ccc(cc3)-n3cnnn3)CC2)C1=O

InChI Key InChIKey=KURKDEGYKLJJNZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363475   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM363475(9-(2-(4-(1H-tetrazol-1- yl)phenyl)-2-hydroxyethyl)...)
Affinity DataIC50:  4.80nMAssay Description:Blocking of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent