BDBM365173 4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10517878, Compound I-88::US10842799, I-88::US9867833, Compound I-88(S)

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3cccc(Cl)c3)c3nnc(c1)n23

InChI Key InChIKey=SYCYKCJYHIDUFW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365173   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365173(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Affinity DataIC50:  6.36nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365173(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Affinity DataIC50:  6.36nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365173(4-(3-(3-chlorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1- ...)
Affinity DataIC50:  6.36nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent