BDBM370453 (Z)-1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethanone oxime::US10233190, Example 1360

SMILES O\N=C(\CC1c2ccccc2-c2cncn12)C1CCCCC1

InChI Key InChIKey=PPEUMDWFICZDCN-SILNSSARSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 370453   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM370453((Z)-1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol- 5-y...)
Affinity DataIC50:  2.04E+4nMAssay Description:Inhibition of IDO1 in human IFN-gamma stimulated human HeLa cells assessed as inhibition of kynurenine production using L-tryptophan substrate incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM370453((Z)-1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol- 5-y...)
Affinity DataIC50:  550nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent