BDBM370916 US10239843, Example 23
SMILES Cn1c(=O)n(CC2CC2)c2ccc(cc2c1=O)S(=O)(=O)NC1(C)CC1
InChI Key InChIKey=AXMXMMJXTSJFHK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 370916
Affinity DataIC50: 355nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Affinity DataEC50: 440nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 620nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human full length C-terminus His-tagged ARH3 expressed in Escherichia coli using Bt-NAD ribosylated PARP1 substrate after 30 mins by TR...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
The University Of Manchester
Curated by ChEMBL
The University Of Manchester
Curated by ChEMBL
Affinity DataEC50: >1.50E+5nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli using activated DNA as substrate after 60 mins by peroxy glow reagent A/B based assayMore data for this Ligand-Target Pair