BDBM370916 US10239843, Example 23

SMILES Cn1c(=O)n(CC2CC2)c2ccc(cc2c1=O)S(=O)(=O)NC1(C)CC1

InChI Key InChIKey=AXMXMMJXTSJFHK-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 370916   

TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM370916(US10239843, Example 23)
Affinity DataIC50:  355nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM370916(US10239843, Example 23)
Affinity DataEC50:  440nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM370916(US10239843, Example 23)
Affinity DataEC50:  620nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetADP-ribosylhydrolase ARH3(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM370916(US10239843, Example 23)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human full length C-terminus His-tagged ARH3 expressed in Escherichia coli using Bt-NAD ribosylated PARP1 substrate after 30 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
The University Of Manchester

Curated by ChEMBL
LigandPNGBDBM370916(US10239843, Example 23)
Affinity DataEC50: >1.50E+5nMAssay Description:Inhibition of human PARP1 expressed in Escherichia coli using activated DNA as substrate after 60 mins by peroxy glow reagent A/B based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed