BDBM372905 6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-((1S,6R)-2-oxa-5-azabicyclo[4.1.0]heptane-5-carbonyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-1-fluorovinyl)nicotinonitrile::US10246429, Example 311::US10246429, Example 312
SMILES C[C@@]1(N=C(N)S[C@]2(C[C@@H]12)C(=O)N1CCO[C@H]2C[C@@H]12)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F
InChI Key InChIKey=XYFWWLGMDVICID-DLQDBSQJSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 372905
Affinity DataIC50: 1.80nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CatD is 0.05M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) i...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.81E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CatD is 0.05M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) i...More data for this Ligand-Target Pair