BDBM372994 US10597366, Compound 74::US9896418, Compound 74

SMILES OCc1c(Br)c(Oc2cc(F)cc(Cl)c2)ccc1S(=O)(=O)C(F)F

InChI Key InChIKey=GREQBABHNZHCOV-UHFFFAOYSA-N

Data  2 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372994   

TargetVascular endothelial growth factor A(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataEC50:  320nMAssay Description:VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM372994(US10597366, Compound 74 | US9896418, Compound 74)
Affinity DataIC50:  150nMAssay Description:HIF-2a: The total assay volume was about 100 uL in the following configuration: 2 uL compound in 100% DMSO, 88 uL buffer with protein and probe and 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB