BDBM373520 US10421747, Compound 3::US9902714, Compound 3
SMILES COc1cc(O)c2CN(CCN(c3ccc4ncc(nc4c3)-c3cnn(C)c3)c2c1)C(C)C
InChI Key InChIKey=QHSZDLZQQBWEOS-UHFFFAOYSA-N
Data 10 Kd
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 373520
Affinity DataKd: 720nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 620nMAssay Description:FGFR2: In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0....More data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:FGFR3: In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 1.90E+3nMAssay Description:FGFR4: In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astex Therapeutics
US Patent
Astex Therapeutics
US Patent
Affinity DataKd: >3.00E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 720nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 620nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 1.90E+3nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astex Therapeutics
US Patent
Astex Therapeutics
US Patent
Affinity DataKd: >3.00E+3nMAssay Description:KDR (VEGFR2): In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO...More data for this Ligand-Target Pair