BDBM373609 1-(6-(4-Chlorophenoxy)-4-(piperidin-1-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid;::US10246442, Example 63::US10975062, Example 63

SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1

InChI Key InChIKey=WHTPCGGTHJCPIJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373609   

TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM373609(1-(6-(4-Chlorophenoxy)-4-(piperidin-1-yl)quinazoli...)
Affinity DataIC50:  25.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1 [182-426](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373609(1-(6-(4-Chlorophenoxy)-4-(piperidin-1-yl)quinazoli...)
Affinity DataIC50:  25.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent