BDBM373612 1-(4-(Azepan-1-yl)-6-(4-chlorophenoxy)quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid;::US10246442, Example 66::US10975062, Example 66

SMILES OC(=O)c1cnn(c1)-c1nc(N2CCCCCC2)c2cc(Oc3ccc(Cl)cc3)ccc2n1

InChI Key InChIKey=KAOZNINLEXKJDG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373612   

TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM373612(1-(4-(Azepan-1-yl)-6-(4-chlorophenoxy)quinazolin-2...)
Affinity DataIC50:  31.6nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1 [182-426](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373612(1-(4-(Azepan-1-yl)-6-(4-chlorophenoxy)quinazolin-2...)
Affinity DataIC50:  31.6nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent