BDBM374609 US10246457, Example 18

SMILES Cn1cc(cn1)-c1cc(cc2c(N)n[nH]c12)-c1cccc(NC(=O)c2cc3CCCCc3s2)c1CO

InChI Key InChIKey=BMSPLGRRCSYHSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374609   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM374609(US10246457, Example 18)
Affinity DataIC50:  11.6nMAssay Description:Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM374609(US10246457, Example 18)
Affinity DataIC50:  0.130nMAssay Description:Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent