BDBM375315 (4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(morpholino)methanone::US9908886, Example 2

SMILES Oc1ccc(cc1)-c1cnc2cnc(cn12)-c1ccc(cc1)C(=O)N1CCOCC1

InChI Key InChIKey=FXUCGEVPOQUSIH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 375315   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50: <1.00E+3nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50: <1.00E+3nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  130nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  113nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)
Affinity DataIC50:  125nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed