BDBM376906 6-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidin-2-yl]-decahydro-1,6-naphthyridine hydrochloride (E39)::US9920053, Example 39

SMILES Fc1cccc(Oc2cc(nc(n2)N2CCC3NCCCC3C2)C(F)(F)F)c1

InChI Key InChIKey=SKEFXGBGLIGVDP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 376906   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376906(6-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidi...)
Affinity DataIC50:  1.26nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376906(6-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidi...)
Affinity DataIC50:  631nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376906(6-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidi...)
Affinity DataIC50:  3.02E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376906(6-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidi...)
Affinity DataIC50:  30.9nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent