BDBM377731 5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide::US10266513, Example 25::US10266513, Example 26::US10266513, Example 27::US10815213, Example 27

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(F)cc2F)cc1)C1CCCN(C1)C#N

InChI Key InChIKey=SQFDBQCBXUWICP-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 377731   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  2.18nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  17.3nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  1.30nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  1.68E+4nMAssay Description:EGFR: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide subs...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  2.18nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  17.3nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  1.30nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377731(5-amino-1-(1-cyanopiperidin-3-yl)-3-[4-(2,4-difluo...)
Affinity DataIC50:  1.68E+4nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide substrate ...More data for this Ligand-Target Pair
In DepthDetails US Patent