BDBM379557 US9926281, Compound 36
SMILES Cc1ccc(Cl)cc1N1CCN(CC1)C(=O)CCC1(NC(=O)NC1=O)C1CC1
InChI Key InChIKey=IYBHJPNFVKYDOX-UHFFFAOYSA-N
Data 26 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 379557
Affinity DataIC50: 29nMAssay Description:ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...More data for this Ligand-Target Pair
Affinity DataIC50: 6.78E+3nMAssay Description:Inhibition of MMP-12 (unknown origin)More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos
US Patent
Galapagos
US Patent
Affinity DataIC50: 670nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of the proteases human MMP1 was determined at REACTION BIOLOGY (Reaction Biology Corp. 1 Great Valley Parkway, Suite 2 Malvern, Pa. 19355,...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:MMP2: Protocol 1: The basis for the assay is the cleavage of the substrate 520 MMP fret substrate XV (Anaspec, Catalog #: AS-60582-01) by human MMP2 ...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:MMP-14:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP14 (Biomol, Cat #SE-259...More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos
Curated by ChEMBL
Galapagos
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assayMore data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 1(Homo sapiens (Human))
Galapagos
Curated by ChEMBL
Galapagos
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAM...More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Galapagos
Curated by ChEMBL
Galapagos
Curated by ChEMBL
Affinity DataIC50: 428nMAssay Description:Inhibition of human recombinant ADAMTS-4 (AA1 to 520) assessed as cleavage of fluorescent substrate using as TBIS-1 substrate incubated for 180 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of human recombinant MMP2 (AA34 to 660) assessed as cleavage of fluorescent substrate using 390 MMP FRET as substrate incubated for 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MMP14 (AA112 to 298) assessed as cleavage of fluorescent substrate using 390 MMP FRET as substrate incubated for 30 m...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos
US Patent
Galapagos
US Patent
Affinity DataIC50: 651nMAssay Description:Inhibition of human recombinant TACE (AA34 to 660) assessed as cleavage of fluorescent substrate using 5FAM-LAQAVRSSSRK-5TAMRA as substrate by bioche...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 9(Homo sapiens (Human))
Galapagos
Curated by ChEMBL
Galapagos
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of ADAM-9 (unknown origin)More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Galapagos
Curated by ChEMBL
Galapagos
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of ADAM-10 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Caspase 3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of DPP-IV (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MMP-7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MMP-8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MMP-9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos
Curated by ChEMBL
Galapagos
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:ADAMTS-5:Protocol 1: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair