BDBM381158 3-((4-((4-(3-(5-(tert-Butyl)-3-((2-(dimethylamino)acetamido)methyl)-2-methoxyphenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)benzamide::US9890185, Example 77

SMILES COCCOCCOCCNC(=O)c1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CNC(=O)CN(C)C)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OC)c1

InChI Key InChIKey=FPWCREKHIZDTGO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 381158   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM381158(3-((4-((4-(3-(5-(tert-Butyl)-3-((2-(dimethylamino)...)
Affinity DataIC50:  20nMAssay Description:Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM381158(3-((4-((4-(3-(5-(tert-Butyl)-3-((2-(dimethylamino)...)
Affinity DataIC50:  2.62E+3nMAssay Description:Method 1: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM381158(3-((4-((4-(3-(5-(tert-Butyl)-3-((2-(dimethylamino)...)
Affinity DataIC50:  51nMAssay Description:Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM381158(3-((4-((4-(3-(5-(tert-Butyl)-3-((2-(dimethylamino)...)
Affinity DataIC50:  17nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent