BDBM390938 US9957264, Example 5-9::tert-butyl (3R,4R)-4- (cyanomethyl)-3-fluoro-4- {3-[(2-methyl-1,1-dioxido- 2,3-dihydro-1,2- benzisothiazol-5-yl) amino]-4-oxo-4,5-dihydro- 1H-pyrazolo[4,3-c] pyridin-1-yl}piperidine- 1-carboxylate (from I-6-2B)
SMILES CN1Cc2cc(Nc3nn(c4cc[nH]c(=O)c34)[C@@]3(CC#N)CCN(C[C@H]3F)C(=O)OC(C)(C)C)ccc2S1(=O)=O
InChI Key
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 390938
Affinity DataIC50: 0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair