BDBM390938 US9957264, Example 5-9::tert-butyl (3R,4R)-4- (cyanomethyl)-3-fluoro-4- {3-[(2-methyl-1,1-dioxido- 2,3-dihydro-1,2- benzisothiazol-5-yl) amino]-4-oxo-4,5-dihydro- 1H-pyrazolo[4,3-c] pyridin-1-yl}piperidine- 1-carboxylate (from I-6-2B)

SMILES CN1Cc2cc(Nc3nn(c4cc[nH]c(=O)c34)[C@@]3(CC#N)CCN(C[C@H]3F)C(=O)OC(C)(C)C)ccc2S1(=O)=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390938   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM390938(US9957264, Example 5-9 | tert-butyl (3R,4R)-4- (cy...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM390938(US9957264, Example 5-9 | tert-butyl (3R,4R)-4- (cy...)
Affinity DataIC50:  0.100nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent