BDBM390972 (2S,5S)-tert-butyl 5- (cyanomethyl)-5-(3-((4- (N,N- dimethylsulfamoyl)phenyl) amino)-4-oxo-4,5-dihydro- 1H-pyrazolo[4,3-c]pyridin- 1-yl)tetrahydro-2H-pyran- 2-carboxylate (from I-14-1A)::US9957264, Example 5-43

SMILES CN(C)S(=O)(=O)c1ccc(Nc2nn(c3cc[nH]c(=O)c23)[C@]2(CC#N)CC[C@H](OC2)C(=O)OC(C)(C)C)cc1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390972   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM390972((2S,5S)-tert-butyl 5- (cyanomethyl)-5-(3-((4- (N,N...)
Affinity DataIC50:  0.140nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM390972((2S,5S)-tert-butyl 5- (cyanomethyl)-5-(3-((4- (N,N...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent