BDBM391001 US9957264, Example 5-72::methyl 4-{3-[(2-ethyl-1,1- dioxo-2,3-dihydro-1,2- benzothiazol-5-yl)amino]-4- oxo-1H,4H,5H-pyrazolo [4,3-c]pyridin-1-yl}-4- (cyanomethyl)piperidine- 1-carboxylate

SMILES CCN1Cc2cc(Nc3nn(c4cc[nH]c(=O)c34)C3(CC#N)CCN(CC3)C(=O)OC)ccc2S1(=O)=O

InChI Key InChIKey=OPEXKUHHCQDSCD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391001   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391001(US9957264, Example 5-72 | methyl 4-{3-[(2-ethyl-1,...)
Affinity DataIC50:  0.260nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391001(US9957264, Example 5-72 | methyl 4-{3-[(2-ethyl-1,...)
Affinity DataIC50:  0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent