BDBM391003 US9957264, Example 5-74::methyl 4-(cyanomethyl)-4- (3-{[2-(cyclopropylmethyl)- 1,1-dioxo-2,3-dihydro-1,2- benzothiazol-5-yl]amino}- 4-oxo-1H,4H,5H-pyrazolo [4,3-c]pyridin-1-yl) piperidine-1-carboxylate

SMILES COC(=O)N1CCC(CC#N)(CC1)n1nc(Nc2ccc3c(CN(CC4CC4)S3(=O)=O)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=NPGRFVWWRRRWNJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391003   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391003(US9957264, Example 5-74 | methyl 4-(cyanomethyl)-4...)
Affinity DataIC50:  0.270nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391003(US9957264, Example 5-74 | methyl 4-(cyanomethyl)-4...)
Affinity DataIC50:  0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent