BDBM391025 (2S,5S)-tert-butyl 5-(3-((4- ((1H-1,2,3-triazol-1- yl)methyl)phenyl)amino)- 4-oxo-4,5-dihydro-1H- pyrazolo[4,3-c]pyridin-1- yl)-5-(cyanomethyl) tetrahydro-2H-pyran-2- carboxylate (from I-14-1A)::US9957264, Example 5-96

SMILES CC(C)(C)OC(=O)[C@@H]1CC[C@](CC#N)(CO1)n1nc(Nc2ccc(Cn3ccnn3)cc2)c2c1cc[nH]c2=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391025   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391025((2S,5S)-tert-butyl 5-(3-((4- ((1H-1,2,3-triazol-1-...)
Affinity DataIC50:  0.340nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391025((2S,5S)-tert-butyl 5-(3-((4- ((1H-1,2,3-triazol-1-...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent