BDBM391102 US9957264, Example 5-173::US9957264, Example 5-174::{(1R,2R)-1-[3-({4-[(1R or 1S)-1-(ethylamino)-2,2,2- trifluoroethyl]phenyl} amino)-4-oxo-4,5- dihydro-1H-pyrazolo [4,3-c]pyridin-1-yl]-2- fluorocyclohexyl} acetonitrile (from I-19A. Derived from Peak A via SFC on pyridone: AS-H, 20% MEOH + 0.25% DMEA in CO2, Tr = 4.4 minutes)

SMILES CCNC(c1ccc(Nc2nn(c3cc[nH]c(=O)c23)[C@@]2(CC#N)CCCC[C@H]2F)cc1)C(F)(F)F

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 391102   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391102(US9957264, Example 5-173 | US9957264, Example 5-17...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391102(US9957264, Example 5-173 | US9957264, Example 5-17...)
Affinity DataIC50:  0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391102(US9957264, Example 5-173 | US9957264, Example 5-17...)
Affinity DataIC50:  0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391102(US9957264, Example 5-173 | US9957264, Example 5-17...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent