BDBM391107 US9957264, Example 5-178::[(3S)-3-{3-[(2-tert-butyl- 1,1-dioxido-2,3-dihydro- 1,2-benzisothiazol-5-yl) amino]-4-oxo-4,5-dihydro- 1H-pyrazolo[4,3-c] pyridin-1-yl}tetrahydro- 2H-pyran-3-yl] acetonitrile (from I-17B)

SMILES CC(C)(C)N1Cc2cc(Nc3nn(c4cc[nH]c(=O)c34)[C@]3(CC#N)CCCOC3)ccc2S1(=O)=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391107   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391107(US9957264, Example 5-178 | [(3S)-3-{3-[(2-tert-but...)
Affinity DataIC50:  0.170nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391107(US9957264, Example 5-178 | [(3S)-3-{3-[(2-tert-but...)
Affinity DataIC50:  0.0400nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent