BDBM391152 (2S,5S)-tert-butyl 5-(3-((2- carbamoylquinolin-6- yl)amino)-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl)-5- (cyanomethyl)tetrahydro- 2H-pyran-2-carboxylate (from I-14-1A)::US9957264, Example 5-223

SMILES CC(C)(C)OC(=O)[C@@H]1CC[C@](CC#N)(CO1)n1nc(Nc2ccc3nc(ccc3c2)C(N)=O)c2c1cc[nH]c2=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391152   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391152((2S,5S)-tert-butyl 5-(3-((2- carbamoylquinolin-6- ...)
Affinity DataIC50:  0.820nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391152((2S,5S)-tert-butyl 5-(3-((2- carbamoylquinolin-6- ...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent