BDBM391180 2-(4-(3-((2-(tert-butyl)- 1,1-dioxido-2,3- dihydrobenzo[d]isothiazol-5- yl)amino)-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl)tetrahydro- 2H-pyran-4-yl)acetonitrile::US9957264, Example 5-251

SMILES CC(C)(C)N1Cc2cc(Nc3nn(c4cc[nH]c(=O)c34)C3(CC#N)CCOCC3)ccc2S1(=O)=O

InChI Key InChIKey=BVOCKGYWTIFBJM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391180   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391180(2-(4-(3-((2-(tert-butyl)- 1,1-dioxido-2,3- dihydro...)
Affinity DataIC50:  0.780nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391180(2-(4-(3-((2-(tert-butyl)- 1,1-dioxido-2,3- dihydro...)
Affinity DataIC50:  0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent