BDBM391187 2-((3R,4R or 3S,4S)-3- fluoro-4-(3-((3-methyl-4- (morpholine-4- carbonyl)phenyl)amino)-4- oxo-4,5-dihydro-1H- pyrazolo[4,3-c]pyridin-1- yl)tetrahydro-2H-pyran-4- yl)acetonitrile (derived from I-22A)::US9957264, Example 5-258

SMILES Cc1cc(Nc2nn(c3cc[nH]c(=O)c23)[C@]2(CC#N)CCOC[C@@H]2F)ccc1C(=O)N1CCOCC1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391187   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391187(2-((3R,4R or 3S,4S)-3- fluoro-4-(3-((3-methyl-4- (...)
Affinity DataIC50:  0.0800nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391187(2-((3R,4R or 3S,4S)-3- fluoro-4-(3-((3-methyl-4- (...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent