BDBM394401 2-(6-amino-5-(4-(pyridin-::US10308614, Example 3

SMILES Nc1nnc(cc1N1CCN(Cc2cccnc2)CC1)-c1ccccc1O

InChI Key InChIKey=JZLOJEOBZZJRHN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394401   

TargetTranscription activator BRG1 [1448-1575](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394401(2-(6-amino-5-(4-(pyridin- | US10308614, Example 3)
Affinity DataIC50:  37.3nMAssay Description:His-BRG1 (A1448-S1575; Swiss Prot P51532; mhhhhhhgslvpr\gsAEKLSPNPP NLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNH KYRSLNDLEKDVMLLCQNA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein polybromo-1 [645-766](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394401(2-(6-amino-5-(4-(pyridin- | US10308614, Example 3)
Affinity DataIC50:  25.2nMAssay Description:Histidine-Flag-PB1-BD5 Bromodomain645-766 (S645-D766; Swiss Prot Q86U86; mhhhhhhasdykddddkgslvpr\gsSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAI FLRLPSRSEL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM394401(2-(6-amino-5-(4-(pyridin- | US10308614, Example 3)
Affinity DataIC50:  60.7nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvpr\gsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent