BDBM395537 (S)-1-(4-((3′-(5-(((R)-3-carboxypyrrolidin-1-yl)methyl)-7-chlorobenzo[d]oxazol-2-yl)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)methoxy)-5-chloro-2-((5-cyanopyridin-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid::US10308644, Example 149::US10800768, Example 149::US11339149, Example 149

SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN3CCCC[C@H]3C(O)=O)cc2Cl)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(Cl)c3o2)c1C

InChI Key InChIKey=GBRIGZRDFCLLRD-YOOWCYLZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 395537   

TargetProgrammed cell death 1 ligand 1 [19-238]/protein 1 [25-167](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM395537((S)-1-(4-((3′-(5-(((R)-3-carboxypyrrolidin-1...)
Affinity DataIC50:  55nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProgrammed cell death 1 ligand 1 [19-238]/protein 1 [25-167](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM395537((S)-1-(4-((3′-(5-(((R)-3-carboxypyrrolidin-1...)
Affinity DataIC50:  55nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProgrammed cell death 1 ligand 1 [19-238]/protein 1 [25-167](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM395537((S)-1-(4-((3′-(5-(((R)-3-carboxypyrrolidin-1...)
Affinity DataIC50:  750nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent