BDBM396035 US10308660, Example 137

SMILES Cn1c(nc(N)c(-c2cccc(Cl)c2Cl)c1=O)N1CCC2(CC(F)(F)C[C@H]2N)CC1

InChI Key InChIKey=QSOLKRRNJYIKQE-CYBMUJFWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 396035   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM396035(US10308660, Example 137)
Affinity DataIC50:  22nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent