BDBM397428 US9987278, Compound Reference 38

SMILES CCCNc1nc(Nc2ccc(cc2)C#N)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C

InChI Key InChIKey=HJFSVYUFOXAVAA-YUAYGMJFSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 397428   

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Homo sapiens (Human))
Fujifilm

US Patent
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50: <1nMAssay Description:Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM397428(US9987278, Compound Reference 38)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed