BDBM399565 US10323036, Compound I-8::US10793574, Compound I-8::US11220508, Compound I-8
SMILES COc1c(Nc2cc(Nc3cc(C)c(F)cn3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
InChI Key InChIKey=QGFLBFPUIQMKKD-UHFFFAOYSA-N
Data 3 Kd
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 399565
TargetNon-receptor tyrosine-protein kinase TYK2 [V731I](Homo sapiens (Human))
Nimbus Lakshmi
US Patent
Nimbus Lakshmi
US Patent
Affinity DataKd: <0.100nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshmi
US Patent
Nimbus Lakshmi
US Patent
Affinity DataKd: <0.100nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Homo sapiens (Human))
Nimbus Lakshmi
US Patent
Nimbus Lakshmi
US Patent
Affinity DataKd: <0.100nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...More data for this Ligand-Target Pair