BDBM399927 (6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl-6-fluoro-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide ::US10323042, Example 7::US10738063, Example 7

SMILES F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F

InChI Key InChIKey=QMOPFHQOZKALTC-ZETCQYMHSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 399927   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  6.51nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  31.4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  306nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of full length human PDE4B1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  306nMAssay Description:A portion of the human PDE4D3 coding sequence (amino acids 50 to 672 from the sequence with accession number Q08499-2) was cloned into the baculoviru...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  31nMAssay Description:Inhibition of full length human PDE4C1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length human PDE4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  6.51nMAssay Description:Human PDE4B1 coding sequence (amino acids 122 to 736 from the sequence with accession number Q07343) with the mutations resulting in the amino acid s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  2nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  31.4nMAssay Description:Human PDE4C1 coding sequence (amino acids 2 to 712 from the sequence with accession number NP_000914.2) was cloned into the baculovirus expression ve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM399927((6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl...)
Affinity DataIC50:  306nMAssay Description:Inhibition of full length human PDE4D3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed