BDBM402341 6-(3-(2-chloro-4-((4- cyclopropyl-1-(2,6- dichlorophenyl)-1H-pyrazol- 5-yl)methoxy)phenyl)-3- hydroxyazetidin-1-yl)-5- fluoronicotinic acid::US10329286, Example 11::US11247986, Example 11

SMILES OC(=O)c1cnc(N2CC(O)(C2)c2ccc(OCc3c(cnn3-c3c(Cl)cccc3Cl)C3CC3)cc2Cl)c(F)c1

InChI Key InChIKey=YXBSANGYUBIGCK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402341   

TargetBile acid receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM402341(6-(3-(2-chloro-4-((4- cyclopropyl-1-(2,6- dichloro...)
Affinity DataEC50:  3.80nMAssay Description:Expression and purification of the FXR-LBD: An overnight preculture of a transformed E. coli strain was diluted 1:20 in LB-Ampicillin medium and grow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBile acid receptor [187-472](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM402341(6-(3-(2-chloro-4-((4- cyclopropyl-1-(2,6- dichloro...)
Affinity DataEC50:  3.80nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent