BDBM402588 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-cyanothiophen-3- yl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 13

SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3cscc3C#N)n2n1

InChI Key InChIKey=KNULTVKMGBOXKO-UONOGXRCSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402588   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402588(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(4-cyanot...)
Affinity DataIC50:  4nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent