BDBM402731 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-bromothiophen-3- yl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 38

SMILES N[C@H]1CCCC[C@H]1Nc1ncc2ccc(C(=O)Nc3ccsc3Br)n2n1

InChI Key InChIKey=DXPRYYQPCMDTJK-NWDGAFQWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402731   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402731(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(2-bromot...)
Affinity DataIC50:  7nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent