BDBM402836 2-[(3R,5R)-3-amino-5- fluoropiperidin-1-yl]-N-[1- methyl-3- (trifluoromethyl)-1H- pyrazol-4-yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 149

SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H](N)C[C@@H](F)C2)c(n1)C(F)(F)F

InChI Key InChIKey=SPFJXZLDVRYPFS-NXEZZACHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402836   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402836(2-[(3R,5R)-3-amino-5- fluoropiperidin-1-yl]-N-[1- ...)
Affinity DataIC50:  0.800nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent