BDBM402850 2-[(3R,5S)-3-amino-5- fluoropiperidin-1-yl]-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 163

SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H](N)C[C@H](F)C2)c(n1)C(F)F

InChI Key InChIKey=HCIOYANIHDFNCX-VHSXEESVSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402850   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402850(2-[(3R,5S)-3-amino-5- fluoropiperidin-1-yl]-N-[3- ...)
Affinity DataIC50:  0.700nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent