BDBM410356 US10377770, Example 116::rac-trans-2-(1,1-Difluoroethyl)-N-(3-(5-(hydroxymethyl)-1,2,4,4a,5,6-hexahydro-[1,4]oxazino[4,3-a][1,5]naphthyridin-9-yl)-4-methylphenyl)isonicotinamide

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(C)(F)F)cc1-c1cnc2CC(CO)C3COCCN3c2c1

InChI Key InChIKey=CTAJXKFOFSOHKM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 410356   

TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM410356(US10377770, Example 116 | rac-trans-2-(1,1-Difluor...)
Affinity DataIC50: <0.00200nMAssay Description:The activity of a compound according to the present invention can be assessed by well-known in vitro & in vivo methods. Raf inhibition data provided ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent