BDBM411584 US10392391, Compound I-N-13::US10787452, Compound I-N-13::US11117900, Compound I-N-13::US11370798, Cmpd. # I-N-13::US20230271963, Compound I-N-13

SMILES Nc1nn2cc(F)cnc2c1C(=O)Nc1cncc(F)c1N1CCN(CC1)C1COC1

InChI Key InChIKey=QXUPKSMOTFIYQY-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 411584   

LigandPNGBDBM411584(US10392391, Compound I-N-13 | US10787452, Compound...)
Affinity DataKi: <200nMAssay Description:Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM411584(US10392391, Compound I-N-13 | US10787452, Compound...)
Affinity DataKi:  550nMAssay Description:Table 5: Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out i...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent