BDBM413451 2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-7-methyl-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one::US10407446, Example 4::US11136340, Example 4

SMILES Cc1nc2cc(C)c(Nc3ncc4n(C)c(=O)n(C5CCOCC5)c4n3)cn2n1

InChI Key InChIKey=HVAUFHFQTYQRDP-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 413451   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  7.94E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  7.94E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreenŽ Eu Kinase Binding assay run by ThermoFisher Scientific as part of ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413451(2-((2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  1.26nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent