BDBM414462 N-[6-Chloro-2-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2H-indazol-5-yl]-6-(2-hydroxypropan-2-yl)pyridine-2-carboxamide::US10435396, Example 32

SMILES CC(C)(O)c1cccc(n1)C(=O)Nc1cc2cn(nc2cc1Cl)C1CCS(=O)(=O)CC1

InChI Key InChIKey=DARNQLSKIDRYKQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 414462   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Bayer Pharma Aktiegesellschaft

US Patent
LigandPNGBDBM414462(N-[6-Chloro-2-(1,1-dioxidotetrahydro-2H-thiopyran-...)
Affinity DataIC50:  34nMAssay Description:For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM solution of the test substance in DMSO....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent