BDBM414705 US10435405, Example 122::US10934288, Example 122

SMILES CNCc1cc(F)c(c(F)c1)-c1cc2c(n[nH]c2cn1)-c1cnn(C)c1

InChI Key InChIKey=UCUVIFYGOBXXKX-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 414705   

LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataKi:  5.40nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: >2.50E+4nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50:  117nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50: >2.50E+4nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50:  366nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))TBA
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50:  1.08E+3nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM414705(US10435405, Example 122 | US10934288, Example 122)
Affinity DataIC50:  2.60E+3nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed