BDBM417049 4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide::US10456394, Example 2
SMILES ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1
InChI Key InChIKey=MNAYBFFSFQRSIT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 64 hits for monomerid = 417049
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.22E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of full length human recombinant HDAC8 using RHKKAcKAc-AMC fluorogenic peptide as substrate incubated for 2 hrs by microplate reader assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: >3.00E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 1.10E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 4.55E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.90nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 4.07E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
Affinity DataIC50: 3.34E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 3.46E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: >3.00E+4nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 746nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.22E+3nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.91nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC6 CD2 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase incubated for 2 hrs followed by NanoBRET NanoGl...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells u...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC1 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human full length recombinant HDAC2 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
University Of East Anglia
Curated by ChEMBL
University Of East Anglia
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human full length recombinant HDAC3/ NcoR2 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC8 using p53 (379 to 382 residues) (RHK(Ac)K(Ac)AMC as substrate preincubated for 5 to 10 mins followe...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human full length recombinant HDAC4 using p53 (379 to 382 residues) Ac-LGK(TFA)-AMC as substrate preincubated for 5 to 10 mins followed...More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC5 using p53 (379 to 382 residues) Ac-LGK(TFA)-AMC as substrate preincubated for 5 to 10 mins followed...More data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC7 using p53 (379 to 382 residues) Ac-LGK(TFA)-AMC as substrate preincubated for 5 to 10 mins followed...More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC9 using p53 (379 to 382 residues) Ac-LGK(TFA)-AMC as substrate preincubated for 5 to 10 mins followed...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human full length recombinant HDAC10 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed ...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human full length recombinant HDAC11 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length recombinant HDAC6 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.90nMAssay Description:Inhibition of full length recombinant human HDAC1 expressed in baculovirus infected Sf9 insect cells using RHKKAc fluorogenic peptide as substrate pr...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of full length recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using RHKKAc fluorogenic peptide as substrate pr...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human HDAC6 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 769nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of recombinant human HDAC8 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 282nMAssay Description:Inhibition of recombinant human HDAC2 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-GAK(Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of recombinant human HDAC5 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 511nMAssay Description:Inhibition of recombinant human HDAC7 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human HDAC9 using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of recombinant human HDAC11 expressed in HEK293T/17 cells using Boc-Lys(TFA)-AMC as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 90nMAssay Description:Inhibition of Nanoluc-fused HDAC1 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NANOBRET assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 60nMAssay Description:Inhibition of Nanoluc-fused HDAC6 CD2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NANOBRET assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataEC50: 160nMAssay Description:Inhibition of HDAC6 in human RPMI-8226 cells assessed as increase in tubulin acetylation incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant human full-length HDAC6 using RHKK(Ac)AMC as substrate preincubated for 5 to 10 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of full-length recombinant human HDAC1 using RHKKAc peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.28E+4nMAssay Description:Inhibition of full-length recombinant human HDAC2 using RHKKAc peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of full-length recombinant human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of full-length recombinant human HDAC5 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full-length recombinant human HDAC6 using RHKKAc peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
The Board of Trustees of The University of Illinois
US Patent
The Board of Trustees of The University of Illinois
US Patent
Affinity DataIC50: 4.55E+3nMAssay Description:Inhibition of full-length recombinant human HDAC7 using Boc-Lys(trifluoroacetyl)-AMC peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of full-length recombinant human HDAC8 using RHKAcKAc peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair