BDBM418007 US10457669, Example 1083::US10457669, Example 685::US11001575, Example 685

SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl

InChI Key InChIKey=BVRGQPJKSKKGIH-PUAOIOHZSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 418007   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418007(US10457669, Example 1083 | US10457669, Example 685...)
Affinity DataIC50:  2.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418007(US10457669, Example 1083 | US10457669, Example 685...)
Affinity DataIC50:  2.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418007(US10457669, Example 1083 | US10457669, Example 685...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418007(US10457669, Example 1083 | US10457669, Example 685...)
Affinity DataIC50:  2.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418007(US10457669, Example 1083 | US10457669, Example 685...)
Affinity DataIC50:  2.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair