BDBM426369 US10526325, Compound A45::US10829489, Compound A45
SMILES C[C@@](O)(C(=O)N1CCc2c(C1)ncn2-c1ccc(Cl)cc1)C(F)(F)F
InChI Key InChIKey=VEKVAVGNILVOKU-OAHLLOKOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 426369
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Merck Patent
US Patent
Merck Patent
US Patent
Affinity DataKd: <300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Merck Patent
US Patent
Merck Patent
US Patent
Affinity DataKd: <300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair