BDBM426413 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-fluoroimidazo[1,2-a]pyrazin-8-yl)oxy)-2-methylpiperidin-1-yl)methanone::US10526336, Example 32

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1nccn2c(F)cnc12

InChI Key InChIKey=FKIJOIAFJRXYNY-HUUCEWRRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426413   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426413((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-fl...)
Affinity DataIC50:  1.17E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426413((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-fl...)
Affinity DataIC50:  12.6nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent